Obesity promotes 7,12-dimethylbenz(a)anthracene-induced mammary tumor development in female zucker rats

Abstract

High body mass index has been associated with increased risk for various cancers, including breast cancer. Here we describe studies using 7,12-dimethylbenz(a)anthracene (DMBA) to investigate the role of obesity in DMBA-induced mammary tumor susceptibility in the female Zucker rat (fa/fa), which is the most widely used rat model of genetic obesity. Fifty-day… (More)
DOI: 10.1186/bcr1263

Topics

4 Figures and Tables

Cite this paper

@article{Hakkak2005ObesityP7, title={Obesity promotes 7,12-dimethylbenz(a)anthracene-induced mammary tumor development in female zucker rats}, author={Reza Hakkak and Andy W Holley and Stewart L. Macleod and Pippa M Simpson and George Joseph Fuchs and Chan Hee Jo and Thomas Kieber-Emmons and Soheila Korourian}, journal={Breast Cancer Research}, year={2005}, volume={7}, pages={R627 - R633} }