Obesity modifies bone marrow microenvironment and directs bone marrow mesenchymal cells to adipogenesis.

@article{Silva2016ObesityMB,
  title={Obesity modifies bone marrow microenvironment and directs bone marrow mesenchymal cells to adipogenesis.},
  author={Simone Vargas da Silva and Mariana Renovato-Martins and Cristiane Ribeiro-Pereira and Marta Citelli and Christina Barja-Fidalgo},
  journal={Obesity},
  year={2016},
  volume={24 12},
  pages={2522-2532}
}
OBJECTIVE To investigate the role of obesity on the bone marrow microenvironment and evaluate its possible impact on the adipogenic potential of mesenchymal stem cells (MSC). METHODS C57BL/6 male mice were fed with a high-fat diet (HFD) for 10 weeks. Femurs and tibiae were collected, and bone marrow mesenchymal stem cells (BM-MSC) were isolated and… CONTINUE READING