Obesity is associated with tissue-specific activation of renal angiotensin-converting enzyme in vivo: evidence for a regulatory role of endothelin.

@article{Barton2000ObesityIA,
  title={Obesity is associated with tissue-specific activation of renal angiotensin-converting enzyme in vivo: evidence for a regulatory role of endothelin.},
  author={Matthias Barton and Renata Carmona and Henning Morawietz and Livius V D'uscio and Winfried Goettsch and Heinz Hillen and Christian C. Haudenschild and Jos{\'e} Eduardo Krieger and Klaus Muenter and Thomas Lattmann and Thomas Felix L{\"u}scher and Sidney Shaw},
  journal={Hypertension},
  year={2000},
  volume={35 1 Pt 2},
  pages={329-36}
}
In the C57BL/6J mice model, we investigated whether obesity affects the function or expression of components of the tissue renin-angiotensin system and whether endothelin (ET)-1 contributes to these changes. ACE activity (nmol. L His-Leu. mg protein(-1)) was measured in lung, kidney, and liver in control (receiving standard chow) and obese animals treated for 30 weeks with a high-fat, low cholesterol diet alone or in combination with LU135252, an orally active ET(A) receptor antagonist. ACE… CONTINUE READING

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