Obesity is a determinant of asthma control independent of inflammation and lung mechanics.

@article{Farah2011ObesityIA,
  title={Obesity is a determinant of asthma control independent of inflammation and lung mechanics.},
  author={Claude S Farah and Jessica A. Kermode and Sue R. Downie and Nathan J. Brown and Kate Marie Hardaker and Norbert Berend and Gregory G. King and Cheryl M. Salome},
  journal={Chest},
  year={2011},
  volume={140 3},
  pages={
          659-666
        }
}
BACKGROUND It is unclear why obesity is associated with worse asthma control. We hypothesized that (1) obesity affects asthma control independent of spirometry, airway inflammation, and airway hyperresponsiveness (AHR) and (2) residual symptoms after resolution of inflammation are due to obesity-related changes in lung mechanics. METHODS Forty-nine subjects with asthma underwent the following tests, before and after 3 months of high-dose inhaled corticosteroid (ICS) treatment: five-item… CONTINUE READING

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