Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion.

@article{Chavin1999ObesityIE,
  title={Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion.},
  author={Kenneth D Chavin and Shiqi Yang and Hui Zhi Lin and John Chatham and Vadappuram P. Chacko and Joannes B Hoek and Elisabeth Walajtys-Rode and Asif Rashid and Chun Hong Chen and Charlie Huang and Tie Cheng Wu and Melissa D. Lane and Anna Mae Diehl},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 9},
  pages={5692-700}
}
Uncoupling protein 2 (UCP2) uncouples respiration from oxidative phosphorylation and may contribute to obesity through effects on energy metabolism. Because basal metabolic rate is decreased in obesity, UCP2 expression is predicted to be reduced. Paradoxically, hepatic expression of UCP2 mRNA is increased in genetically obese (ob/ob) mice. In situ hybridization and immunohistochemical analysis of ob/ob livers demonstrate that UCP2 mRNA and protein expression are increased in hepatocytes, which… CONTINUE READING

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