Obesity-induced hypertension: interaction of neurohumoral and renal mechanisms.

  title={Obesity-induced hypertension: interaction of neurohumoral and renal mechanisms.},
  author={John E. Hall and Jussara M. do Carmo and Alexandre A. da Silva and Zhen Wang and Michael E. Hall},
  journal={Circulation research},
  volume={116 6},
Excess weight gain, especially when associated with increased visceral adiposity, is a major cause of hypertension, accounting for 65% to 75% of the risk for human primary (essential) hypertension. Increased renal tubular sodium reabsorption impairs pressure natriuresis and plays an important role in initiating obesity hypertension. The mediators of abnormal kidney function and increased blood pressure during development of obesity hypertension include (1) physical compression of the kidneys by… 

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