Obesity induced by high-fat diet promotes insulin resistance in the ovary.

  title={Obesity induced by high-fat diet promotes insulin resistance in the ovary.},
  author={Eliana Akamine and Anderson Carlos Marçal and Jo{\~a}o Paulo Gabriel Camporez and Mara Sandra Hoshida and Luciana Chagas Caperuto and Estela Bevilacqua and Carla Roberta de Oliveira Carvalho},
  journal={The Journal of endocrinology},
  volume={206 1},
Besides the effects on peripheral energy homeostasis, insulin also has an important role in ovarian function. Obesity has a negative effect on fertility, and may play a role in the development of the polycystic ovary syndrome in susceptible women. Since insulin resistance in the ovary could contribute to the impairment of reproductive function in obese women, we evaluated insulin signaling in the ovary of high-fat diet-induced obese rats. Female Wistar rats were submitted to a high-fat diet for… CONTINUE READING
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