Obesity increases blood pressure, cerebral vascular remodeling, and severity of stroke in the Zucker rat.

Abstract

Obesity is a risk factor for stroke, but the mechanisms by which obesity increases stroke risk are unknown. Because microvascular architecture contributes to the outcome of stroke, we hypothesized that middle cerebral arteries (MCAs) from obese Zucker rats (OZRs) undergo inward remodeling and develop increased myogenic tone compared with those in lean… (More)
DOI: 10.1161/HYPERTENSIONAHA.108.124149

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