Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta.

@article{Challier2008ObesityIP,
  title={Obesity in pregnancy stimulates macrophage accumulation and inflammation in the placenta.},
  author={J. C. Challier and Sreemanti Basu and T. Bintein and Judi Minium and K A Hotmire and Patrick Michael Catalano and Sylvie Hauguel-de Mouzon},
  journal={Placenta},
  year={2008},
  volume={29 3},
  pages={274-81}
}
Obesity and pregnancy are associated with a combination of insulin resistance and inflammatory changes which exacerbate in combination. Based on the similarity between the inflammatory transcriptomes of adipose tissue and placenta, we hypothesized that the placenta develops exaggerated inflammation in response to obesity. The aim of this study was to characterize placental inflammatory mediators and macrophage accumulation in relation to peripheral inflammation in obesity. Placental macrophages… CONTINUE READING
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