Obesity-driven inflammation and cancer risk: role of myeloid derived suppressor cells and alternately activated macrophages.

@article{OkwanDuodu2013ObesitydrivenIA,
  title={Obesity-driven inflammation and cancer risk: role of myeloid derived suppressor cells and alternately activated macrophages.},
  author={Derick Okwan-Duodu and Guillermo E Umpierrez and Otis W Brawley and Roberto Diaz},
  journal={American journal of cancer research},
  year={2013},
  volume={3 1},
  pages={21-33}
}
During carcinogenesis, tumors induce dysfunctional development of hematopoietic cells. Myeloid lineage cells, in the form of myeloid derived suppressor cells (MDSCs) and alternatively polarized M2 macrophages, influence almost all types of cancers by regulating diverse facets of immunosuppression, angiogenesis, cell proliferation, growth and metastasis. One-third of Americans are obese, and accumulating evidence suggests that obesity is a risk factor for various cancers. However, the… CONTINUE READING