Obesity-associated variants within FTO form long-range functional connections with IRX3

@inproceedings{Smemo2014ObesityassociatedVW,
  title={Obesity-associated variants within FTO form long-range functional connections with IRX3},
  author={Scott Smemo and Juan J. Tena and Kyoung-han Kim and Eric R. Gamazon and Noboru J. Sakabe and Carlos G{\'o}mez-Mar{\'i}n and I M S Aneas and Flavia L. Credidio and D{\'e}bora R. Sobreira and Nora F. Wasserman and Ju Hee Lee and Vijitha Puviindran and Davis Tam and Michael Shen and Joe Eun Son and Niki Alizadeh Vakili and Hoon-Ki Sung and Silvia Naranjo and Rafael D. Acemel and Miguel Manzanares and Andras D Nagy and Nancy J. Cox and Chi-Chung Hui and Jos{\'e} Luis G{\'o}mez-Skarmeta and Marcelo A. Nobrega},
  booktitle={Nature},
  year={2014}
}
Genome-wide association studies (GWAS) have reproducibly associated variants within introns of FTO with increased risk for obesity and type 2 diabetes (T2D). Although the molecular mechanisms linking these noncoding variants with obesity are not immediately obvious, subsequent studies in mice demonstrated that FTO expression levels influence body mass and composition phenotypes. However, no direct connection between the obesity-associated variants and FTO expression or function has been made… CONTINUE READING
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Genome - wide association studies ( GWAS ) have reproducibly associated variants within introns of FTO with increased risk for obesity and type 2 diabetes ( T2D ) .
Genome - wide association studies ( GWAS ) have reproducibly associated variants within introns of FTO with increased risk for obesity and type 2 diabetes ( T2D ) .
Genome - wide association studies ( GWAS ) have reproducibly associated variants within introns of FTO with increased risk for obesity and type 2 diabetes ( T2D ) .
Genome - wide association studies ( GWAS ) have reproducibly associated variants within introns of FTO with increased risk for obesity and type 2 diabetes ( T2D ) .
Genome - wide association studies ( GWAS ) have reproducibly associated variants within introns of FTO with increased risk for obesity and type 2 diabetes ( T2D ) .
Genome - wide association studies ( GWAS ) have reproducibly associated variants within introns of FTO with increased risk for obesity and type 2 diabetes ( T2D ) .
Genome - wide association studies ( GWAS ) have reproducibly associated variants within introns of FTO with increased risk for obesity and type 2 diabetes ( T2D ) .
Genome - wide association studies ( GWAS ) have reproducibly associated variants within introns of FTO with increased risk for obesity and type 2 diabetes ( T2D ) .
Genome - wide association studies ( GWAS ) have reproducibly associated variants within introns of FTO with increased risk for obesity and type 2 diabetes ( T2D ) .
Genome - wide association studies ( GWAS ) have reproducibly associated variants within introns of FTO with increased risk for obesity and type 2 diabetes ( T2D ) .
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