Obesity-associated insulin resistance in skeletal muscle: Role of lipid accumulation and physical inactivity

@article{Eckardt2011ObesityassociatedIR,
  title={Obesity-associated insulin resistance in skeletal muscle: Role of lipid accumulation and physical inactivity},
  author={Kristin Eckardt and Annika Taube and J{\"u}rgen Eckel},
  journal={Reviews in Endocrine and Metabolic Disorders},
  year={2011},
  volume={12},
  pages={163-172}
}
An alarming increase in the prevalence of obesity, type 2 diabetes mellitus, and associated diseases can be observed world-wide during the past 20 years. In obesity, profound alterations in the secretion profile of adipokines and inflammatory markers as well as increased lipolysis occur, leading besides other events to elevated levels of free fatty acids, which in turn are distributed to nonadipose tissue such as skeletal muscle. While the amount of intramyocellular lipids can be used as a… CONTINUE READING
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Lipid oxidation is reduced in obese human skeletal muscle.

American journal of physiology. Endocrinology and metabolism • 2000
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