Obesity-associated autoantibody production requires AIM to retain the immunoglobulin M immune complex on follicular dendritic cells.

@article{Arai2013ObesityassociatedAP,
  title={Obesity-associated autoantibody production requires AIM to retain the immunoglobulin M immune complex on follicular dendritic cells.},
  author={Satoko Arai and Natsumi Maehara and Yoshihiro Iwamura and Shin-ichiro Honda and Katsuhiko Nakashima and Toshihiro Kai and Masato Ogishi and Kumiko Morita and Jun Kurokawa and Mayumi Mori and Yuji Motoi and Kensuke Miyake and Nobuyuki Matsuhashi and Ken-ichi Yamamura and Osamu Ohara and Akira Shibuya and Edward K. Wakeland and Quanzhen Li and Toru Miyazaki},
  journal={Cell reports},
  year={2013},
  volume={3 4},
  pages={1187-98}
}
Natural immunoglobulin M (IgM) is reactive to autoantigens and is believed to be important for autoimmunity. Blood pentameric IgM loaded with antigens forms a large immune complex (IC) that contains various elements, including apoptosis inhibitor of macrophage (AIM). Here we demonstrate that this IgM-AIM association contributes to autoantibody production under obese conditions. In mice fed a high-fat diet, natural IgM increased through B cell TLR4 stimulation. AIM associated with IgM and… CONTINUE READING
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