Obesity and the human microbiome

@article{Ley2010ObesityAT,
  title={Obesity and the human microbiome},
  author={Ruth E. Ley},
  journal={Current Opinion in Gastroenterology},
  year={2010},
  volume={26},
  pages={5–11}
}
  • R. Ley
  • Published 1 January 2010
  • Biology, Medicine
  • Current Opinion in Gastroenterology
Purpose of review Obesity was once rare, but the last few decades have seen a rapid expansion of the proportion of obese individuals worldwide. Recent work has shown obesity to be associated with a shift in the representation of the dominant phyla of bacteria in the gut, both in humans and animal models. This review summarizes the latest research into the association between microbial ecology and host adiposity, and the mechanisms by which microbes in the gut may mediate host metabolism in the… 
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705 Citations
Highly Influential Citations
19
Background Citations
259
Methods Citations
7
Results Citations
17

705 Citations

Citation Type

Citation Type

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The Gut Microbiome and Obesity
TLDR
Modulation of the gut microbiome through diet, pre- and probiotics, antibiotics, surgery, and fecal transplantation has the potential to majorly impact the obesity epidemic.
The role of gut microbiota in human obesity: recent findings and future perspectives.
  • A. Tagliabue, M. Elli
  • Biology, Medicine
    Nutrition, metabolism, and cardiovascular diseases : NMCD
  • 2013
Diet, Gut Microbiota and Obesity
TLDR
The recent advances of mechanisms through which gut microbiota dysbiosis leads to obesity are discussed, and the underlying causes of obesity-related gut microbiota, highlighting dietary effects are discussed.
Anti-obesity effects of gut microbiota are associated with lactic acid bacteria
TLDR
The cause of obesity is described, including the genetic and environmental factors, and the mechanisms by which the gut microbiota influence energy metabolism and inflammation in obesity are described.
Molecular ecological tools to decipher the role of our microbial mass in obesity.
TLDR
This review aims to describe the different molecular approaches and their contributions to the understanding of the role of the GI microbiota in host energy homeostasis, and suggests that an OAMD associated microbiota can be characterised by a potential pro-inflammatory composition.
The role of intestinal microbiota in energy metabolism and metabolic discorders.
TLDR
A metagenomic and integrative metabolomic approach could help in the discovery of which bacteria, among the trillions in the human gut, are specifically involved in the control of host energy metabolism.
Targeting gut microbiota in obesity: effects of prebiotics and probiotics
TLDR
The gut microbiota is a potential nutritional and pharmacological target in the management of obesity and obesity-related disorders and suggests that specific phyla, classes or species of bacteria, or bacterial metabolic activities could be beneficial or detrimental to patients with obesity.
The gut microbial metabolome: modulation of cancer risk in obese individuals
TLDR
Only if the link between microbial diversity and metabolic functionality is firmly established, will the mechanism by which gut microbiota maintains health or contributes to disease development be elucidated.
Diet effects in gut microbiome and obesity.
TLDR
Discoveries in the interrelationship between diet, intestinal microbiome, and body immune system provide us novel perceptions to the specific action mechanisms and will promote the development of therapeutic approaches for obesity.
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