Obesity and metabolic syndrome in histone demethylase JHDM2a‐deficient mice

@article{Inagaki2009ObesityAM,
  title={Obesity and metabolic syndrome in histone demethylase JHDM2a‐deficient mice},
  author={T. Inagaki and M. Tachibana and K. Magoori and Hiromi Kudo and Toshiya Tanaka and Masashi Okamura and M. Naito and T. Kodama and Y. Shinkai and J. Sakai},
  journal={Genes to Cells},
  year={2009},
  volume={14}
}
Histone H3 lysine 9 (H3K9) methylation is a crucial epigenetic mark of heterochromatin formation and transcriptional silencing. Recent studies demonstrated that most covalent histone lysine modifications are reversible and the jumonji C (JmjC)‐domain‐containing proteins have been shown to possess such demethylase activities. However, there is little information available on the biological roles of histone lysine demethylation in intact animal model systems. JHDM2A (JmjC‐domain‐containing… Expand
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