Obesity and intermittent hypoxia increase tumor growth in a mouse model of sleep apnea.

@article{Almendros2012ObesityAI,
  title={Obesity and intermittent hypoxia increase tumor growth in a mouse model of sleep apnea.},
  author={Isaac Almendros and Josep Mar{\'i}a Montserrat and Marta Torres and Maria R Bonsignore and Laura Chimenti and Daniel Navajas and Ramon Farr{\'e}},
  journal={Sleep medicine},
  year={2012},
  volume={13 10},
  pages={1254-60}
}
BACKGROUND Intermittent hypoxia and obesity which are two pathological conditions commonly found in patients with obstructive sleep apnea (OSA), potentially enhance cancer progression. OBJECTIVE To investigate whether obesity and/or intermittent hypoxia (IH) mimicking OSA affect tumor growth. METHODS A subcutaneous melanoma was induced in 40 mice [22 obese (40-45g) and 18 lean (20-25g)] by injecting 10(6) B16F10 cells in the flank. Nineteen mice (10 obese/9 lean) were subjected to IH (6h… CONTINUE READING
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