Obesity and impaired fibrinolysis: role of adipose production of plasminogen activator inhibitor-1

@article{Skurk2004ObesityAI,
  title={Obesity and impaired fibrinolysis: role of adipose production of plasminogen activator inhibitor-1},
  author={Thomas Skurk and Hans Hauner},
  journal={International Journal of Obesity},
  year={2004},
  volume={28},
  pages={1357-1364}
}
Obesity is the central promoter of the metabolic syndrome which also includes disturbed fibrinolysis in addition to hypertension, dyslipidaemia and impaired glucose tolerance/type 2 diabetes mellitus. Plasminogen activator inhibitor-1 (PAI-1) is the most important endogenous inhibitor of tissue plasminogen activator and uro-plasminogen activator, and is a main determinant of fibrinolytic activity. There is now compelling evidence that obesity and, in particular, an abdominal type of body fat… CONTINUE READING