Obesity and endocrine therapy: host factors and breast cancer outcome.

@article{Goodwin2013ObesityAE,
  title={Obesity and endocrine therapy: host factors and breast cancer outcome.},
  author={Pamela Jean Goodwin},
  journal={Breast},
  year={2013},
  volume={22 Suppl 2},
  pages={S44-7}
}
Obesity is becoming increasingly prevalent and it has been linked to poor breast cancer outcomes. Because obesity is associated with increased adipose tissue mass and aromatase activity [the target of aromatase inhibitors (AIs)], there is concern that these agents may be less effective in women who are overweight or obese. Four of the randomized trials of AIs vs. tamoxifen conducted in the adjuvant breast cancer setting (ATAC, BIG 1-98 and TEAM in the postmenopausal setting and ABCSG-12 in the… CONTINUE READING