Obesity and diabetes: Tissue targeting of oestrogen

Abstract

This study showed that lipoxin A4 is an endogenous allosteric enhancer of cannabioid receptor 1 (CB1). Lipoxin A4 increased the affinity of the endogenous cannabinoid anandamide for CB1, and reduction of lipoxin A4 levels in mice reduced the cataleptic effect of anandamide, showing that lipoxin A4 modulates endocannabinoid signalling. Moreover, lipoxin A4… (More)
DOI: 10.1038/nrd3934

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