Obesity and IL-6 interact in modulating the response to endotoxemia in mice.

@article{Pini2013ObesityAI,
  title={Obesity and IL-6 interact in modulating the response to endotoxemia in mice.},
  author={Maria Pini and Karla Josephine Castellanos and Davina H. Rhodes and Giamila Fantuzzi},
  journal={Cytokine},
  year={2013},
  volume={61 1},
  pages={
          71-7
        }
}
Obesity is associated with elevated levels of IL-6. High IL-6 is prognostic of mortality in sepsis, while controversial data link obesity to sepsis outcome. We used Lean and diet-induced obese (DIO) WT and IL-6 KO mice to investigate the interaction between obesity and IL-6 in endotoxemia. Circulating levels of IL-6 were significantly higher in WT DIO versus WT Lean mice receiving LPS (2.5 μg/mouse, ip). Obesity lead to greater weight loss in response to LPS, with IL-6 deficiency being… CONTINUE READING
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