Obesity alters circadian expressions of molecular clock genes in the brainstem.

@article{Kaneko2009ObesityAC,
  title={Obesity alters circadian expressions of molecular clock genes in the brainstem.},
  author={Keizo Kaneko and Tetsuya Yamada and Sohei Tsukita and Kei S Takahashi and Yasushi Ishigaki and Yoshitomo Oka and Hideki Katagiri},
  journal={Brain research},
  year={2009},
  volume={1263},
  pages={58-68}
}
Major components of energy homeostasis, including feeding behavior and glucose and lipid metabolism, are subject to circadian rhythms. Recent studies have suggested that dysfunctions of molecular clock genes are involved in the development of obesity and diabetes. To examine whether metabolic states per se alter the circadian clock in the central nervous system (CNS), we analyzed the daily mRNA expression profiles of core clock genes in the caudal brainstem nucleus of the solitary tract (NTS… CONTINUE READING

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