Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation.

@article{Xu2013ObesityAA,
  title={Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation.},
  author={Xiaoyuan Xu and Ambar Grijalva and Alicja A. Skowronski and Marco van Eijk and Mireille J Serlie and Anthony W. Ferrante},
  journal={Cell metabolism},
  year={2013},
  volume={18 6},
  pages={816-30}
}
Obesity activates a complex systemic immune response that includes the recruitment of macrophages and other immune cells to key metabolic tissues. Current models postulate that obesity and excess lipids classically activate macrophages, polarizing them toward an M1 (inflammatory) state. Little is known about noninflammatory functions of adipose tissue… CONTINUE READING