Obesity accelerates hair thinning by stem cell-centric converging mechanisms.

  title={Obesity accelerates hair thinning by stem cell-centric converging mechanisms.},
  author={Hironobu Morinaga and Yasuaki Mohri and Marina Grachtchouk and Kyosuke Asakawa and Hiroyuki Matsumura and Motohiko Oshima and Naoya Takayama and Tomoki Kato and Yuriko Nishimori and Yuriko Sorimachi and Keiyo Takubo and Takayoshi Suganami and Atsushi Iwama and Yoichirou Iwakura and Andrzej A. Dlugosz and Emi K. Nishimura},
Obesity is a worldwide epidemic that predisposes individuals to many age-associated diseases, but its exact effects on organ dysfunction are largely unknown1. Hair follicles-mini-epithelial organs that grow hair-are miniaturized by ageing to cause hair loss through the depletion of hair follicle stem cells (HFSCs)2. Here we report that obesity-induced stress, such as that induced by a high-fat diet (HFD), targets HFSCs to accelerate hair thinning. Chronological gene expression analysis revealed… Expand
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