Obesity: Inhibiting PI3K reduces body weight in obese mice


Treating mice with CNIO-PI3Ki (an inhibitor of PI3K) results in progressive weight loss, according to new research published in Cell Metabolism. Diet-induced obese mice were treated with the inhibitor for 10 days, while being maintained on a high-fat diet. At the end of the treatment period, the mice had lost weight despite their food intake remaining constant. The most effective dosage (CNIO-PI3Ki at 15 mg/kg) resulted in the treated mice achieving the same body weight as control mice on a standard diet within 10 days of initiating treatment. “In my opinion the response of the obese mice has features that I am not aware have been ever observed before with other antiobesity drugs,” says corresponding author Manuel Serrano. Obese rhesus macaques treated with CNIO-PI3Ki for 3 months also showed reduced adiposity. The researchers suggest that CNIOPI3Ki works by activating thermogenesis in brown adipocytes, which increases OBESITY

DOI: 10.1038/nrendo.2015.60

Cite this paper

@article{Greenhill2015ObesityIP, title={Obesity: Inhibiting PI3K reduces body weight in obese mice}, author={Claire J. Greenhill}, journal={Nature Reviews Endocrinology}, year={2015}, volume={11}, pages={317-317} }