Obesity Defined as Excess Storage of Inert Triglycerides – Do We Need a Paradigm Shift?

  title={Obesity Defined as Excess Storage of Inert Triglycerides – Do We Need a Paradigm Shift?},
  author={Thorkild I. A. S{\o}rensen},
  journal={Obesity Facts},
  pages={91 - 94}
Obesity affects three domains of individual life: the physical effects of the body size and weight, the psychosocial effects of the abnormal body image and the various metabolic effects predisposing to a broad panel of co-morbidities. In this editorial, I will argue for the need of a fundamental revision of the concept of obesity as a health problem primarily in the latter domain. The argument is based on the accumulating evidence that the stored triacylglyceride (TAG) is an inert biochemical… 
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The naive interpretation of the cumulative positive energy balance is inadequate in the understanding of the development of obesity because the quantity of fat accumulated per day is on average so small that measurement of it is beyond any available technique.
Challenges in Understanding Development of Obesity
This chapter shows how this intuitively obvious, but in reality naive, concept can lead to fundamental flaws in the understanding of the development of obesity and hence potentially misguide the research in obesity as well as the management of the obesity problem in both preventive and therapeutic settings.
Obesity: lessons from evolution and the environment
The 9th Stock Conference acknowledged the complex background of genetic, cultural, environmental and evolutionary factors of obesity. Gene–environment interactions underlie the flexibility in
Adipose Tissue Expansion for Improving Glycemic Control
Indications are that further research may creatively uncouple the adipogenic and antiglycemic effects to improve obesity-associated metabolic abnormalities independent of weight loss.
Functional body composition and related aspects in research on obesity and cachexia: report on the 12th Stock Conference held on 6 and 7 September 2013 in Hamburg, Germany
  • M. Müller, V. Baracos, S. Heymsfield
  • Biology, Medicine
    Obesity reviews : an official journal of the International Association for the Study of Obesity
  • 2014
The 12th Stock Conference addressed body composition and related functions in two extreme situations, obesity and cancer cachexia, and supported Michael Stocks' concept of gaining new insights by integrating research ideas from obesity andcancer cachexia.
Harnessing the beneficial properties of adipogenic microbes for improving human health
New approaches to improve metabolic comorbidities independent of weight loss are examined and human adenovirus 36 (Ad36) and specific gut microbes were examined for their potential to influence lipid and glucose homeostasis in animals and humans.
Independent association of liver fat accumulation with insulin resistance.
Do rapid BMI growth in childhood and early-onset obesity offer cardiometabolic protection to obese adults in mid-life? Analysis of a longitudinal cohort study of Danish men
There was no evidence that rapid BMI growth in childhood or early-onset obesity was associated with either MHO or the MANW phenotype, for example, among obese men in mid-life, the OR for MHO comparing early-ONSet obesity with non-early-onsets obesity was 0.97 (95% CI 0.85 to 1.10).
Association of HS6ST3 gene polymorphisms with obesity and triglycerides: gene × gender interaction
Genetic associations of 117 single-nucleotide polymorphisms within the HS6ST3 gene with obesity and triglycerides are examined using two Caucasian samples and demonstrate the importance of gender differences in the aetiology.
Gender Differences and Obesity Influence on Pulmonary Function Parameters
In the studied population, males exhibited higher mean values of PFT parameters than females, and increased BMI may be associated with a restrictive pattern on spirometry.


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  • T. Sørensen
  • Medicine
    Proceedings of the Nutrition Society
  • 2008
Limits of the energy balance model warrant cautiousness in using the model in studies of obesity causation, and particular opportunities for the identification of the causes of the obesity epidemic by detailed analysis of an observed irregular development of the epidemic over long time periods are presented.
Issues and Misconceptions About Obesity
The intent of this article is to provide direct access to the considerations that pertain to particular notions commonly cited in the context of obesity, under separate headings, that should be helpful to individuals not necessarily immersed in obesity research who want to understand the meaning of specific terms and concepts.
Adipose tissue expandability: the metabolic problems of obesity may arise from the inability to become more obese.
Some of the evidence suggesting that the risk of developing metabolic disturbances is not related to how much fat an individual has, but how well their fat can expand to accommodate the caloric excess is explored.
Body composition and body fat distribution in relation to later risk of acute myocardial infarction: a Danish follow-up study
Obesity was positively associated with MI, and classical estimates of abdominal obesity and BIA estimates of obesity showed significant positive associations with incident MI, however, BFM adjusted for WC showed no association.
Comparison of the Relative Contributions of Intra‐Abdominal and Liver Fat to Components of the Metabolic Syndrome
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Lifelong doubling of mortality in men entering adult life as obese
Men entering adult life as obese experience a lifelong doubling of mortality, a finding that strongly supports the continued need to avoid beginning adult lifeAs obese.
Body fat and fat-free mass and all-cause mortality.
The findings suggest that BMI represents joint but opposite associations of body fat and FFM with mortality, and both high bodyfat and low FFM are independent predictors of all-cause mortality.