Obesity--is it a genetic disorder?

  title={Obesity--is it a genetic disorder?},
  author={Ruth J F Loos and Claude Bouchard},
  journal={Journal of internal medicine},
  volume={254 5},
Obesity is one of the most pressing problems in the industrialized world. Twin, adoption and family studies have shown that genetic factors play a significant role in the pathogenesis of obesity. Rare mutations in humans and model organisms have provided insights into the pathways involved in body weight regulation. Studies of candidate genes indicate that some of the genes involved in pathways regulating energy expenditure and food intake may play a role in the predisposition to obesity… CONTINUE READING
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