Obesity: The two faces of fat

@article{Powell2007ObesityTT,
  title={Obesity: The two faces of fat},
  author={Kendall Powell},
  journal={Nature},
  year={2007},
  volume={447},
  pages={525-527}
}
No longer viewed as inert packets of energy, fat cells are two-faced masterminds of metabolism. Kendall Powell weighs up the differences between 'fat' fat cells and thin ones. 
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References

SHOWING 1-10 OF 11 REFERENCES
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.
TLDR
A role for TNF-alpha in obesity and particularly in the insulin resistance and diabetes that often accompany obesity is indicated.
Obesity is associated with macrophage accumulation in adipose tissue.
TLDR
Transcript expression in perigonadal adipose tissue from groups of mice in which adiposity varied due to sex, diet, and the obesity-related mutations agouti (Ay) and obese (Lepob) found that the expression of 1,304 transcripts correlated significantly with body mass.
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
TLDR
It is shown that obesity causes endoplasmic reticulum (ER) stress, which leads to suppression of insulin receptor signaling through hyperactivation of c-Jun N-terminal kinase (JNK) and subsequent serine phosphorylation of insulin receptors substrate–1 (IRS-1).
Mice Lacking Adiponectin Show Decreased Hepatic Insulin Sensitivity and Reduced Responsiveness to Peroxisome Proliferator-activated Receptor γ Agonists*
TLDR
Adiponectin is an important contributor to PPARγ-mediated improvements in glucose tolerance through mechanisms that involve the activation of the AMPK pathway.
Acquirement of Brown Fat Cell Features by Human White Adipocytes*
TLDR
It is shown that PGC-1α is able to direct human WAT PPARγ toward a transcriptional program linked to energy dissipation, and that Alteration of energy balance through an increased utilization of fat in WAT may be a conceivable strategy for the treatment of obesity.
Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes
TLDR
It is demonstrated that chemical chaperones enhance the adaptive capacity of the ER and act as potent antidiabetic modalities with potential application in the treatment of type 2 diabetes.
Intention to Lose Weight, Weight Changes, and 18-y Mortality in Overweight Individuals without Co-Morbidities
TLDR
Deliberate weight loss in overweight individuals without known co-morbidities may be hazardous in the long term, and the health effects of weight loss are complex, possibly composed of oppositely acting processes.
Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects.
TLDR
RBP4 is an adipocyte-secreted molecule that is elevated in the serum before the development of frank diabetes and appears to identify insulin resistance and associated cardiovascular risk factors in subjects with varied clinical presentations, providing a rationale for antidiabetic therapies aimed at lowering serum RBP4 levels.
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
TLDR
Downregulation of GLUT4 and glucose transport selectively in adipose tissue can cause insulin resistance and thereby increase the risk of developing diabetes, as well as developing glucose intolerance and hyperinsulinaemia.
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
TLDR
It is shown that expression of retinol binding protein-4 (RBP4) is elevated in adipose tissue of adipose-Glut4-/- mice and RBP4 is an adipocyte-derived ‘signal’ that may contribute to the pathogenesis of type 2 diabetes.
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