Obesity, male infertility, and the sperm epigenome.

  title={Obesity, male infertility, and the sperm epigenome.},
  author={James R. Craig and Timothy G. Jenkins and Douglas T. Carrell and James M. Hotaling},
  journal={Fertility and sterility},
  volume={107 4},
Obesity is a growing epidemic and a common problem among reproductive-age men that can both cause and exacerbate male-factor infertility by means of endocrine abnormalities, associated comorbidities, and direct effects on the fidelity and throughput of spermatogenesis. Robust epidemiologic, clinical, genetic, epigenetic, and nonhuman animal data support these findings. Recent works in the burgeoning field of epigenetics has demonstrated that paternal obesity can affect offspring metabolic and… CONTINUE READING
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