Obesity, diabetes, and neoplasia in yellow A(vy)/- mice: ectopic expression of the agouti gene.

@article{Yen1994ObesityDA,
  title={Obesity, diabetes, and neoplasia in yellow A(vy)/- mice: ectopic expression of the agouti gene.},
  author={Terence T. T. Yen and Anne Gill and Luciano G Frigeri and Gregory S Barsh and George L. Wolff},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1994},
  volume={8 8},
  pages={479-88}
}
The viable yellow A(vy) mutation results in a mottled yellow mouse that is obese, slightly larger than its nonyellow sibs, and more susceptible to tumor formation in those tissues sensitized by the strain genome. The mutation exhibits variable expressivity resulting in a continuum of coat color phenotypes, from clear yellow to pseudoagouti. The mouse agouti protein is a paracrine signaling molecule that induces hair follicle melanocytes to switch from the synthesis of black pigment to yellow… CONTINUE READING

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