Obesity, autophagy and the pathogenesis of liver and pancreatic cancers.

@article{Aghajan2012ObesityAA,
  title={Obesity, autophagy and the pathogenesis of liver and pancreatic cancers.},
  author={Mariam Aghajan and Ning Li and Michael Karin},
  journal={Journal of gastroenterology and hepatology},
  year={2012},
  volume={27 Suppl 2},
  pages={10-4}
}
Liver and pancreatic cancers are both highly lethal diseases with limited to no therapeutic options for patients. Recent studies suggest that deregulated autophagy plays a role in the pathogenesis of these diseases by perturbing cellular homeostasis and laying the foundation for disease development. While accumulation of p62 upon impaired autophagy has been… CONTINUE READING