• Corpus ID: 11342087

Obesity, alcohol, and tobacco as risk factors for cancers of the esophagus and gastric cardia: adenocarcinoma versus squamous cell carcinoma.

@article{Vaughan1995ObesityAA,
  title={Obesity, alcohol, and tobacco as risk factors for cancers of the esophagus and gastric cardia: adenocarcinoma versus squamous cell carcinoma.},
  author={Thomas L. Vaughan and Scott Davis and Alan Kristal and D. B. Thomas},
  journal={Cancer epidemiology, biomarkers \& prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={1995},
  volume={4 2},
  pages={
          85-92
        }
}
  • T. Vaughan, S. Davis, D. Thomas
  • Published 1 March 1995
  • Medicine
  • Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Adenocarcinomas of the esophagus and gastric cardia were once rare. However, for unknown reasons, their incidence has been increasing rapidly over the past 15 years in the United States and parts of Western Europe. In contrast, the incidence of esophageal squamous cell carcinomas has remained relatively constant. To investigate possible reasons for these diverging incidence rates we analyzed data from two population-based case-control studies of cancers of the esophagus and gastric cardia that… 

Figures and Tables from this paper

Tobacco, alcohol, and socioeconomic status and adenocarcinomas of the esophagus and gastric cardia.

TLDR
Because of the long lag time before risk of these tumors is reduced among ex-smokers, smoking may affect early stage carcinogenesis.

Adenocarcinomas of the esophagus and gastric cardia: medical conditions, tobacco, alcohol, and socioeconomic factors.

  • Z. F. ZhangR. Kurtz S. Harlap
  • Medicine
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 1996
TLDR
It is suggested that medical conditions such as hypertension and iron deficiency may be related to the risk of adenocarcinomas of esophagus and gastric cardia and confirms the moderate risk associated with tobacco smoking.

A prospective study of tobacco, alcohol, and the risk of esophageal and gastric cancer subtypes.

TLDR
For drinkers of more than three alcoholic beveragesper day, compared with those whose intake was up to one drink per day, the authors found significant associations between alcohol intake and ESCC risk but not risk for esophageal, gastric cardia, or gastric noncardia adenocarcinoma.

Body mass index and risk of adenocarcinomas of the esophagus and gastric cardia.

TLDR
Increasing prevalence of obesity in the United States population may have contributed to the upward trends in esophageal and gastric cardia adenocarcinomas.

Tobacco, alcohol and the risk of gastric cancer by sub‐site and histologic type

TLDR
This study did not support the hypothesis that the role of tobacco differs by sub‐site and histologic sub‐type of gastric cancer, and neither intake of alcoholic beverages nor snuff dipping was associated with an increased risk of any type of cardia or Gastric cancer.

Body mass, tobacco and alcohol and risk of esophageal, gastric cardia, and gastric non-cardia adenocarcinoma among men and women in a nested case-control study

TLDR
Overweight increases risk of esophageal and gastric cardia adenocarcinoma, while tobacco smoking increases risk that is not explained by sex differences in risk factor profiles of the studied exposures.

Alcohol consumption and the risks of adenocarcinoma and squamous cell carcinoma of the esophagus.

TLDR
Alcohol intake above the recommended US dietary guidelines significantly increases the risk of ESCC, but not EAC or EGJAC, and smoking modifies the effect of alcohol intake on ESCC risk.

Association between Body Mass and Adenocarcinoma of the Esophagus and Gastric Cardia

TLDR
The primary aim was to precisely estimate the strength of the association while adjusting for potential confounding factors, and the effects of body mass early in life compared with its effects late in life and assessed the relative importance of physical activity and energy intake.

A multiethnic population-based study of smoking, alcohol and body size and risk of adenocarcinomas of the stomach and esophagus (United States)

TLDR
Risks of esophageal and gastric cardia adenocarcinomas increased statistically significantly in a dose-dependent manner with increasing body mass index measured at ages 20 and 40 years and recently.
...

References

SHOWING 1-10 OF 30 REFERENCES

Adenocarcinoma of the esophagus: role of obesity and diet.

TLDR
The findings of an increased risk with obesity and decreased risks with intake of raw fruits and vegetables and dietary fiber provide useful directions to pursue in further investigations of this malignancy.

A case-control study of cancers of the gastric cardia in Italy.

TLDR
Cardia tumours showed a greater familial occurrence of GC than did other sites, with a 7-fold increase in risk for those reporting two first-degree relatives with GC and the authors discuss the rising incidence of adenocarcinomas of the cardia and lower oesophagus that has been reported in some western countries.

Rising incidence of adenocarcinoma of the esophagus and gastric cardia.

TLDR
Cancer incidence data from nine areas of the United States revealed steadily rising rates from 1976 to 1987 of adenocarcinomas of the esophagus and gastric cardia, which disproportionately affected white men and rarely occurred among women.

Vodka consumption, tobacco smoking and risk of gastric cancer in Poland.

TLDR
A multicentre hospital-based incident case-control study with 520 male gastric cancer cases and an equal number of age- and sex-matched controls without cancer has been carried out in Poland to assess potential risks due to smoking and alcohol consumption, it was shown that smoking cigarettes had no significant effect on risk.

Incidence of cancer of the esophagus in the US by histologic type

TLDR
Analysis of data from nine US population‐based cancer registries participating in the Surveillance, Epidemiology, and End Results (SEER) program from 1973 through 1982 suggests that the two major histologic types of esophageal cancer may be of different etiologic origin.

Environmental factors and high risk of esophageal cancer among men in coastal South Carolina.

TLDR
The findings suggest that efforts aimed at reducing tobacco and alcohol use will help to lower the elevated rates of esophageal cancer in coastal South Carolina.

Continuing climb in rates of esophageal adenocarcinoma: an update.

TLDR
The rate of esophageal adenocarcinoma in 1988 to 1990 was three times that in 1976 to 1978, while the rate of squamous cell carcinoma declined by 23%.

Alcohol and cancer.

TLDR
Characteristics of the association between alcohol and cancer may provide clues to causal pathways and all types of alcoholic beverages seem to be implicated, pointing to an etiological role for ethanol or its metabolites.

The rising trend in oesophageal adenocarcinoma and gastric cardia.

  • J. PowellC. McConkey
  • Medicine
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation
  • 1992
TLDR
Comparative analyses indicate a real increase in adenocarcinoma of oesophagus and cardia, although the incidence of both are greater in men than in women, the proportional rates of increase are very similar in both sexes, indicating a common aetiological factor or factors.

Barrett's esophagus and esophageal adenocarcinoma.

  • B. Reid
  • Medicine
    Gastroenterology clinics of North America
  • 1991
TLDR
A systematic protocol of endoscopic biopsy can detect Barrett's adenocarcinomas at an early stage, when they may be curable.