Obesity, Abdominal Obesity and Alzheimer Disease

  title={Obesity, Abdominal Obesity and Alzheimer Disease},
  author={George Razay and Anthea Vreugdenhil and Gordon Wilcock},
  journal={Dementia and Geriatric Cognitive Disorders},
  pages={173 - 176}
Background/Aims: Obesity has a strong association with vascular and metabolic diseases, which have been linked with Alzheimer disease (AD). While recent studies have reported an association between mid-life obesity and dementia, the role of later-life obesity is less clear. This study investigated the relation between AD, obesity and abdominal obesity at later-life in a case-control study. Methods: Participants were 50 consecutive patients with probable AD from memory disorders clinics in… 

Tables from this paper

Increased visceral adipose tissue rather than BMI as a risk factor for dementia.
It is suggested that visceral adipose tissue (VAT) rather than BMI should be considered as a concurrent factor in the development of dementia, and VAT may be reasonably considered to play a predominant role.
Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta‐analysis
  • M. Beydoun, H. Beydoun, Y. Wang
  • Medicine
    Obesity reviews : an official journal of the International Association for the Study of Obesity
  • 2008
A systematic review and meta‐analysis of 10 relevant prospective cohort studies of older adults with end points being dementia and predictors including adiposity measures shows a moderate association between obesity and the risks for dementia and AD.
Association between late-life body mass index and dementia
Higher baseline body mass index (BMI) and slower declining BMI in late life are associated with a reduced risk of dementia, suggesting that low BMI or a faster decline in BMI inLate life may be preclinical indicators of an underlying dementing illness, especially for those who were initially overweight or obese.
Abdominal Fat, Adipose-Derived Hormones and Mild Cognitive Impairment: The J-SHIPP Study
Reduced amounts of subcutaneous fat and low levels of plasma adiponectin were found to be associated with MCI in men, and MCI was not found to been associated with abdominal fat area or adipose-derived hormones in women.
Body Shape and Alzheimer’s Disease: A Mendelian Randomization Analysis
The evidence from MR analyses showed no casual effect of BS on AD risk, which is inconsistent with the results from previous observational studies, and the biological mechanism underlying the findings warrants further study.
Association of Alzheimer’s Disease and Insulin Resistance in King Abdulaziz Medical City, Jeddah
It is suggested that Alzheimer’s disease is associated with IR, and the association may be confounded by many patient-related factors.
Abdominal Obesity and Brain Atrophy in Type 2 Diabetes Mellitus
Abdominal obesity or its downstream effects may partially mediate the adverse effect of T2D on brain atrophy.
Nutritional status according to the stages of Alzheimer’s disease
Patients with AD are mostly elderly with changes in body composition that are typical of aging, with signs of peripheral malnutrition and preservation of abdominal fat, but greater impairment of general nutritional status was observed in the more advanced stages of AD, creating a situation of greater vulnerability for these patients.
The Association between Lifestyle, Anthropometric Measurements, and Obesity in University Students
There is a significant association between certain food type, anthropometric parameters, obesity as well as other diseases including (vitamin D deficiency, kidney problems, bone pain, general weakness, thyroid problems, infertility).
Central obesity is selectively associated with cerebral gray matter atrophy in 15,634 subjects in the UK Biobank
It is found that central obesity, was associated with decreased GM volume and regional associations were found between central obesity and with specific GM subcortical nuclei (thalamus, caudate, pallidum, nucleus accumbens), and no association was found with WM volume or structure, or brain network efficiency.


An 18-year follow-up of overweight and risk of Alzheimer disease.
The data suggest that overweight at high ages is a risk factor for dementia, particularly AD, in women, which may have profound implications for dementia prevention.
Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease.
Obesity at midlife is associated with an increased risk of dementia and AD later in life and the role of weight reduction for the prevention of dementia needs to be further investigated.
Central obesity and the aging brain.
A larger waist-hip ratio may be related to neurodegenerative, vascular, or metabolic processes that affect brain structures underlying cognitive decline and dementia.
Obesity in middle age and future risk of dementia: Midlife obesity increases risk of future dementia
The relation between Alzheimer's disease and obesity throughout adult life in a small case-control study showed that obesity in middle age was associated with increased risk of future dementia.
Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study.
Raised systolic blood pressure and high serum cholesterol concentration, and in particular the combination of these risks, in midlife increased the risk of Alzheimer's disease in later life.
Prevalence and trends in obesity among US adults, 1999-2000.
The increases in the prevalences of obesity and overweight previously observed continued in 1999-2000, and increases occurred for both men and women in all age groups and for non-Hispanic whites, non- Hispanic blacks, and Mexican Americans.
NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older.
Among people with diabetes, the prevalence of metabolic syndrome was very high, and those with diabetes and metabolic syndrome had the highest prevalence of CHD, compared with those with both metabolic syndrome and diabetes, who had the lowest prevalence.
Overweight and obesity in Australia: the 1999–2000 Australian Diabetes, Obesity and Lifestyle Study (AusDiab)
To measure the prevalence of obesity in Australian adults and to examine the associations of obesity with socioeconomic and lifestyle factors, a large sample of adults over the age of 40 was surveyed.