Obcells as Proto-Organisms: Membrane Heredity, Lithophosphorylation, and the Origins of the Genetic Code, the First Cells, and Photosynthesis

@article{Cavaliersmith2001ObcellsAP,
  title={Obcells as Proto-Organisms: Membrane Heredity, Lithophosphorylation, and the Origins of the Genetic Code, the First Cells, and Photosynthesis},
  author={T Cavalier-smith},
  journal={Journal of Molecular Evolution},
  year={2001},
  volume={53},
  pages={555-595}
}
I attempt to sketch a unified picture of the origin of living organisms in their genetic, bioenergetic, and structural aspects. Only selection at a higher level than for individual selfish genes could power the cooperative macromolecular coevolution required for evolving the genetic code. The protein synthesis machinery is too complex to have evolved before membranes. Therefore a symbiosis of membranes, replicators, and catalysts probably mediated the origin of the code and the transition from… CONTINUE READING

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View 6 Excerpts
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Cell-Size Control.

Cold Spring Harbor perspectives in biology • 2016
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 156 references

Aminoacyl-tRNA synthetases, the genetic code, and the evolutionary process.

Microbiology and molecular biology reviews : MMBR • 2000
View 7 Excerpts
Highly Influenced

Self-organizing biochemical cycles.

Proceedings of the National Academy of Sciences of the United States of America • 2000
View 6 Excerpts
Highly Influenced

The Genetic Code Is One in a Million

Journal of Molecular Evolution • 1998
View 4 Excerpts
Highly Influenced

The first living systems: a bioenergetic perspective.

Microbiology and molecular biology reviews : MMBR • 1997
View 13 Excerpts
Highly Influenced

Phylogeny from function: evidence from the molecular fossil record that tRNA originated in replication, not translation.

Proceedings of the National Academy of Sciences of the United States of America • 1994
View 9 Excerpts
Highly Influenced

The code within the codons.

View 7 Excerpts
Highly Influenced

Evolution of the genetic code

JT Wong
Microbiol Sci • 1988
View 5 Excerpts
Highly Influenced

Evolution of anticodons: variations in the genetic code.

Cold Spring Harbor symposia on quantitative biology • 1987
View 15 Excerpts
Highly Influenced

Intracellular protein topogenesis.

Progress in clinical and biological research • 1984
View 6 Excerpts
Highly Influenced

A co-evolution theory of the genetic code.

Proceedings of the National Academy of Sciences of the United States of America • 1975
View 5 Excerpts
Highly Influenced

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