OXYTOCIN AND ADDICTION: A REVIEW

@article{Kovacs1998OXYTOCINAA,
  title={OXYTOCIN AND ADDICTION: A REVIEW},
  author={G. Kovacs and Z. Sarnyai and G. Szab{\'o}},
  journal={Psychoneuroendocrinology},
  year={1998},
  volume={23},
  pages={945-962}
}
Neuropeptides affect adaptive central nervous system processes related to opiate ethanol and cocaine addiction. Oxytocin (OXT), a neurohypophyseal neuropeptide synthesized in the brain and released at the posterior pituitary, also is released in the central nervous system (CNS). OXT acts within the CNS and has been shown to inhibit the development of tolerance to morphine, and to attenuate various symptoms of morphine withdrawal in mice. In rats, intravenous self-administration of heroin was… Expand
Opioids and the hormone oxytocin.
TLDR
Evidence suggests a role for OT as an adjunctive or stand-alone treatment of behavioral, cognitive and emotional deficits associated with substance use, which may be responsible for seeking behavior and relapse. Expand
Chronic methamphetamine treatment induces oxytocin receptor up-regulation in the amygdala and hypothalamus via an adenosine A2A receptor-independent mechanism
TLDR
Results indicate that chronic methamphetamine use can induce profound neuroadaptations of the oxytocinergic receptor system in brain regions associated with stress, emotionality and social bonding and that these neuro Adaptations are independent on the presence of A2A receptors. Expand
Region-specific up-regulation of oxytocin receptor binding in the brain of mice following chronic nicotine administration
TLDR
Direct evidence is provided for nicotine-induced neuroadaptations in the oxytocinergic system, which may be involved in the modulation of nicotine-seeking as well as emotional consequence of chronic drug use. Expand
Oxytocin and Addiction: Potential Glutamatergic Mechanisms
TLDR
The idea that OXT has direct effects on Glu transmission within the reward processing pathway is introduced and may reduce addictive behaviors by restoring abnormal drug-induced changes in the glutamatergic system and in its interactions with other neurotransmitters. Expand
The Effect of Oxytocin on Methamphetamine Addiction
Methamphetamine (MAP), a psychostimulant, is abused all over the world, which remains a major social problem. MAP-induced psychological dependence is the main reason for its abuse. Oxytocin (OT), aExpand
The oxytocin receptor impairs ethanol reward in mice
  • A. Bahi
  • Medicine
  • Physiology & Behavior
  • 2015
TLDR
It is concluded that pharmacological and genetic modulation of the OxtR can modulate the acquisition, extinction, and reinstatement of conditioned reinforcing effects of ethanol. Expand
The role of oxytocin in alcohol and drug abuse
TLDR
The preclinical and clinical literature on the effects of OXT administration on alcohol- and drug-related behaviors are summarized and OXT interactions with the hypothalamic-pituitary-adrenal axis and multiple neurotransmitter systems within addiction circuitry are discussed. Expand
Inhibition by oxytocin of methamphetamine-induced hyperactivity related to dopamine turnover in the mesolimbic region in mice
TLDR
Results suggested that OT inhibited the MAP-induced hyperactivity by altering the DA turnover in the mesolimbic region of mice. Expand
The effects of vasopressin and oxytocin on methamphetamine–induced place preference behaviour in rats
TLDR
It is concluded that methamphetamine treatment can change place preference behaviour in rats and that this change may be partially restored by vasopressin antagonism, but exaggerated by oxytocin. Expand
Complexity of oxytocin׳s effects in a chronic cocaine dependent population
TLDR
The significant increase in the desire for drug and monetary reward as well as the significant decrease in measures of social cognition was small but warrant further study of the effect of oxytocin effect in cocaine dependent subjects. Expand
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