OXPHOS mutations and neurodegeneration.

@article{Koopman2012OXPHOSMA,
  title={OXPHOS mutations and neurodegeneration.},
  author={Werner J. H. Koopman and Felix Distelmaier and Jan A M Smeitink and Peter H G M Willems},
  journal={The EMBO journal},
  year={2012},
  volume={32 1},
  pages={
          9-29
        }
}
Mitochondrial oxidative phosphorylation (OXPHOS) sustains organelle function and plays a central role in cellular energy metabolism. The OXPHOS system consists of 5 multisubunit complexes (CI-CV) that are built up of 92 different structural proteins encoded by the nuclear (nDNA) and mitochondrial DNA (mtDNA). Biogenesis of a functional OXPHOS system further requires the assistance of nDNA-encoded OXPHOS assembly factors, of which 35 are currently identified. In humans, mutations in both… CONTINUE READING
BETA
Tweets
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
SHOWING 1-10 OF 84 CITATIONS, ESTIMATED Infinity% COVERAGE

84 Citations

01020'14'16'18
Citations per Year
Semantic Scholar estimates that this publication has 84 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
SHOWING 1-10 OF 280 REFERENCES

Similar Papers

Loading similar papers…