OXPAT/PAT-1 Is a PPAR-Induced Lipid Droplet Protein That Promotes Fatty Acid Utilization

@article{Wolins2006OXPATPAT1IA,
  title={OXPAT/PAT-1 Is a PPAR-Induced Lipid Droplet Protein That Promotes Fatty Acid Utilization},
  author={N. Wolins and Benjamin K Quaynor and James R. Skinner and A. Tzekov and Michelle A. Croce and Matthew C. Gropler and V. Varma and A. Yao-Borengasser and N. Rasouli and P. Kern and B. Finck and P. Bickel},
  journal={Diabetes},
  year={2006},
  volume={55},
  pages={3418 - 3428}
}
Lipid droplet proteins of the PAT (perilipin, adipophilin, and TIP47) family regulate cellular neutral lipid stores. We have studied a new member of this family, PAT-1, and found that it is expressed in highly oxidative tissues. We refer to this protein as “OXPAT.” Physiologic lipid loading of mouse liver by fasting enriches OXPAT in the lipid droplet tissue fraction. OXPAT resides on lipid droplets with the PAT protein adipophilin in primary cardiomyocytes. Ectopic expression of OXPAT promotes… Expand

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