OXA-58, a novel class D {beta}-lactamase involved in resistance to carbapenems in Acinetobacter baumannii.

@article{Poirel2005OXA58AN,
  title={OXA-58, a novel class D \{beta\}-lactamase involved in resistance to carbapenems in Acinetobacter baumannii.},
  author={Laurent Poirel and Sophie Marqu{\'e} and Claire H{\'e}ritier and Christine Segonds and G{\'e}rard Chabanon and Patrice L. Nordmann},
  journal={Antimicrobial agents and chemotherapy},
  year={2005},
  volume={49 1},
  pages={202-8}
}
A carbapenem-resistant Acinetobacter baumannii strain was isolated in Toulouse, France, in 2003. Cloning and expression in Escherichia coli identified the carbapenem-hydrolyzing beta-lactamase OXA-58, which is weakly related (less than 50% amino acid identity) to other oxacillinases. It hydrolyzed penicillins, oxacillin, and imipenem but not expanded-spectrum cephalosporins. The bla(OXA-58) gene was located on a ca. 30-kb non-self-transferable plasmid. After electrotransformation in the A… CONTINUE READING
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