OXA-163, an OXA-48-related class D β-lactamase with extended activity toward expanded-spectrum cephalosporins.

@article{Poirel2011OXA163AO,
  title={OXA-163, an OXA-48-related class D β-lactamase with extended activity toward expanded-spectrum cephalosporins.},
  author={Laurent Poirel and M. S. A. Castanheira and Am{\'e}lie Carr{\"e}r and Carla Parada Rodriguez and Ronald N. Jones and Jorgelina Smayevsky and Patrice L. Nordmann},
  journal={Antimicrobial agents and chemotherapy},
  year={2011},
  volume={55 6},
  pages={2546-51}
}
Two bla(OXA-48)-like-positive isolates (Klebsiella pneumoniae and Enterobacter cloacae) were recovered in Argentina in 2008 as part of a large-scale survey focused on multidrug resistance in Enterobacteriaceae. In both cases, sequencing identified β-lactamase OXA-163, differing from OXA-48 by a single amino substitution and a 4-amino-acid deletion. OXA-163 hydrolyzed penicillins, ceftazidime, and cefotaxime, whereas OXA-48 did not. However, OXA-163 had a much lower ability to hydrolyze… CONTINUE READING