OX40 costimulation turns off Foxp3+ Tregs.

@article{Vu2007OX40CT,
  title={OX40 costimulation turns off Foxp3+ Tregs.},
  author={Minh Diem Vu and Xiang Xiao and Wenda Gao and Nicolas Degauque and Ming Chen and Alexander Kroemer and Nigel Killeen and Naoto Ishii and Xian Chang Li},
  journal={Blood},
  year={2007},
  volume={110 7},
  pages={
          2501-10
        }
}
OX40 is a recently identified T-cell costimulatory molecule that belongs to the TNF/TNFR superfamily. OX40 can be expressed by both activated T effector cells and Foxp3(+) Tregs. It is well known that OX40 delivers a potent costimulatory signal to T effector cells, but very little is known about the role of OX40 in regulating the suppressor properties of Foxp3(+) Tregs and the de novo generation of new inducible Foxp3(+) Tregs from T effector cells. In the present study, we found, by using a… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 48 REFERENCES

Regulatory T cells, tumor immunity and immunotherapy

  • W. Zou
  • Nat Rev Immunol
  • 2007

SUPPRESSION OF Foxp3 Tregs BY OX40 2509 BLOOD, 1 OCTOBER

  • P Waterhouse, JM Penninger, E Timms
  • For personal use only. on September
  • 2007

OX40 ligand shuts down IL-10-producing regulatory T cells.

  • Tomoki Ito, Yui-Hsi Wang, +5 authors Y Liu
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2006

Toll-like receptor 2 controls expansion and function of regulatory T cells

  • RPM Sutmuller, MHMGM den Brok, M Kramer
  • J Clin Invest
  • 2006