OX1 orexin receptors couple to adenylyl cyclase regulation via multiple mechanisms.

@article{Holmqvist2005OX1OR,
  title={OX1 orexin receptors couple to adenylyl cyclase regulation via multiple mechanisms.},
  author={Tomas G. Holmqvist and Lisa Johansson and Marie Ostman and Sylwia Ammoun and Karl E {\AA}kerman and Jyrki P. Kukkonen},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 8},
  pages={6570-9}
}
In this study, the mechanism of OX(1) orexin receptors to regulate adenylyl cyclase activity when recombinantly expressed in Chinese hamster ovary cells was investigated. In intact cells, stimulation with orexin-A led to two responses, a weak (21%), high potency (EC(50) approximately 1 nm) inhibition and a strong (4-fold), low potency (EC(50) = approximately 300 nm) stimulation. The inhibition was reversed by pertussis toxin, suggesting the involvement of G(i/o) proteins. Orexin-B was… CONTINUE READING
49 Extracted Citations
2 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 49 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-2 of 2 references

Receptor Regulation of Adenylyl Cyclase in CHO Cells 6579 by gest on Sptem er 15

  • M. Cote, G. Guillon, M. D. Payet, N. Gallo-Payet
  • J. Clin. Endocrinol. Metab
  • 2001
1 Excerpt

Receptor Regulation of Adenylyl Cyclase in CHO Cells 6578 by gest on Sptem er 15

  • A. Marjamaki, M. Sato, +4 authors S. M. Lanier
  • J. Biol. Chem. 272,
  • 1997
2 Excerpts

Similar Papers

Loading similar papers…