OVOL2, an Inhibitor of WNT Signaling, Reduces Invasive Activities of Human and Mouse Cancer Cells and Is Down-regulated in Human Colorectal Tumors.

@article{Ye2016OVOL2AI,
  title={OVOL2, an Inhibitor of WNT Signaling, Reduces Invasive Activities of Human and Mouse Cancer Cells and Is Down-regulated in Human Colorectal Tumors.},
  author={Guo-dong Ye and Guang-Bin Sun and Peng Jiao and Chen Chen and Qing-Feng Liu and Xiao-li Huang and Rui Zhang and Wang-Yu Cai and Sheng-nan Li and Jia-fa Wu and Yun-Jia Liu and Rong-Si Wu and Yuan-yuan Xie and E. Cheng Chan and Yih-Cherng Liou and Bo-an Li},
  journal={Gastroenterology},
  year={2016},
  volume={150 3},
  pages={659-671.e16}
}
BACKGROUND & AIMS Activation of WNT signaling promotes the invasive activities of several types of cancer cells, but it is not clear if it regulates the same processes in colorectal cancer (CRC) cells, or what mechanisms are involved. We studied the expression and function of OVOL2, a member of the Ovo family of conserved zinc-finger transcription factors regulated by the WNT signaling pathway, in intestinal tumors of mice and human beings. METHODS We analyzed the expression of OVOL2 protein… CONTINUE READING
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