Corpus ID: 31285180


  author={Rajesh K. Naz and Xiaolong Zhu and Changanamkandath Rajesh},
1. Abstract 2. Introduction 3. Materials and methods 3.1. Differential display technique to obtain testis-specific fragment 3.2. Library screening, and isolation, sequencing and analysis of cDNA 3.3. Rapid amplification of 5' and 3' cDNA ends (RACE) to obtain full-length cDNA 3.4. Northern blot analysis 3.5. Reverse transcription-polymerase chain reaction (RT-PCR)-southern blot procedure 4. Results and Discussion 5. Acknowledgement 6. References 

Figures from this paper

Andropause: Can it be properly diagnosed?
This paper critically examines the criteria for diagnosis and suggests a new criterion, which is expected to properly distinguish a benign and reversible condition currently called andropause from an irreversible condition currentlycalled acute androgynous menopause,Which is the true male version of female menophere. Expand
Issues in the Design and Interpretation of Chronic Toxicity and Carcinogenicity Studies in Rodents: Approaches to Dose Selection
The present report builds on an earlier ILSI RSI working group developed a set of principles for the selection of doses for chronic rodent studies, examining some of the issues that arise and offering new perspectives and approaches for putting the principles into practice. Expand


Ovary-selective genes I: the generation and characterization of an ovary-selective complementary deoxyribonucleic acid library.
These data support the hypothesis that genes expressed selectively or specifically in the ovary are probably essential for the normal functioning of this organ system and may have significant implications for the understanding of ovarian function in molecular terms and for the development of innovative strategies for the promotion of fertility or its control. Expand
Novel human testis‐specific cDNA: Molecular cloning, expression and immunobiological effects of the recombinant protein
Findings indicate that the novel sperm‐specific recombinant TSA‐1 has a role in sperm function and may have applications in the development of a contraceptive vaccine, and in the specific diagnosis and treatment of male infertility. Expand
A novel human prostate-specific gene-1 (HPG-1): molecular cloning, sequencing, and its potential involvement in prostate carcinogenesis.
The novel androgen-responsive HPG-1, which has prostate-specific expression and seems to be involved in carcinogenesis, may have applications in the specific diagnosis and treatment of prostate cancer. Expand
Molecular cloning and developmental expression of the major fibrous sheath protein (FS 75) of rat sperm.
Sequence analysis of the rat FS cDNA revealed anchoring kinase A protein domains and several kinase phosphorylation sites, supporting the idea that this protein plays a crucial role in the motility of spermatozoa. Expand
Molecular cloning and sequencing of cDNA encoding for human FA‐1 antigen
The sperm‐specific human FA‐1 recombinant antigen may find applications in immunocontraception, and diagnosis and treatment of immunoinfertility in humans. Expand
Ovarian Antigens and Infertility
  • B. Dunbar
  • Medicine
  • American journal of reproductive immunology
  • 1989
The development of the mammalian ovary involves the differentiation and proliferation of many different cell types that will ultimately support the growth and maturation of the oocyte, resulting inExpand
Immunologic reactions involving sperm cells and preimplantation embryos.
  • A. Menge, R. Naz
  • Medicine
  • American journal of reproductive immunology and microbiology : AJRIM
  • 1988
The systematic analysis in animals of anti-ertility e-ects after immunization with sperm or testis preparations resulted in a clearer delineation of the affected stages and modes of action. Expand
Recombinant fertilization antigen-1 causes a contraceptive effect in actively immunized mice.
It is suggested that rFA-1 antigen is an exciting candidate for the development of a contraceptive vaccine because of its strong and sperm/testis-specific antibody response that causes a reversible inhibition of fertility by affecting sperm-zona binding and the fertilization process. Expand
Development of antisperm contraceptive vaccine for humans: why and how?
A review of the obstacles in the way of producing anti-sperm contraception and progress to date is presented, indicating that sperm antibodies can block fertilization and one antigen showing promise is FA-1 from human and mouse sperm, effective in reducing rabbit and human fertility. Expand
Immunological Control of Fertility in Female Mice
Females with high titers of antisperm agglutinins in their serum showed a marked reduction in the size of the first litter and in total breeding performance over the 6-month period, which seems likely to reduce the number of spermatozoa which penetrate into the oviduct. Expand