OTUB1 protein suppresses mTOR complex 1 (mTORC1) activity by deubiquitinating the mTORC1 inhibitor DEPTOR.

@article{Zhao2018OTUB1PS,
  title={OTUB1 protein suppresses mTOR complex 1 (mTORC1) activity by deubiquitinating the mTORC1 inhibitor DEPTOR.},
  author={Linlin Zhao and Xinbo Wang and Yue Yu and Lu Deng and Lei Chen and Xiaoping Peng and Chenchen Jiao and Guoli Gao and Xiao Tan and Weijuan Pan and Xin Ge and Ping Wang},
  journal={The Journal of biological chemistry},
  year={2018},
  volume={293 13},
  pages={4883-4892}
}
Mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) integrates various environmental signals to regulate cell growth and metabolism. DEPTOR, also termed DEPDC6, is an endogenous inhibitor of mTORC1 and mTORC2 activities. The abundance of DEPTOR centrally orchestrates the mTOR signaling network. However, the mechanisms by which DEPTOR stability is regulated are still elusive. Here, we report that OTU domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) specifically… CONTINUE READING
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