OTO-104: a sustained-release dexamethasone hydrogel for the treatment of otic disorders.

@article{Piu2011OTO104AS,
  title={OTO-104: a sustained-release dexamethasone hydrogel for the treatment of otic disorders.},
  author={Fabrice Piu and Xiaobo Wang and Rayne Fernandez and Luis A. Dellamary and Andrew H. J. Harrop and Qiang Ye and Jenifer Sweet and Rachel L. Tapp and David F. Dolan and Richard A. Altschuler and J. B. Lichter and Carl R Lebel},
  journal={Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology},
  year={2011},
  volume={32 1},
  pages={
          171-9
        }
}
HYPOTHESIS To investigate whether OTO-104, a poloxamer-based hydrogel containing micronized dexamethasone for intratympanic delivery, can provide long-lasting inner ear exposure and be well tolerated. METHODS OTO-104 was administered intratympanically to guinea pigs and sheep, and its pharmacokinetic and toxicity profiles were examined. RESULTS After a single intratympanic injection of OTO-104 (from 0.6% to 20%, w/w), significant and prolonged exposure to dexamethasone in the inner ear was… CONTINUE READING
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