OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity.

Abstract

ORP3 is an R-Ras interacting oxysterol-binding protein homolog that regulates cell adhesion and is overexpressed in several cancers. We investigated here a novel function of ORP3 dependent on its targeting to both the endoplasmic reticulum (ER) and the plasma membrane (PM). Using biochemical and cell imaging techniques we demonstrate the mechanistic… (More)
DOI: 10.1016/j.yexcr.2014.10.019

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