ORMDL3 contributes to the risk of atherosclerosis in Chinese Han population and mediates oxidized low-density lipoprotein-induced autophagy in endothelial cells.

@article{Ma2015ORMDL3CT,
  title={ORMDL3 contributes to the risk of atherosclerosis in Chinese Han population and mediates oxidized low-density lipoprotein-induced autophagy in endothelial cells.},
  author={Xiaochun Ma and Rongfang Qiu and Jie Ming Dang and Jiangxia Li and Qin Hu and Shan Shan and Qian Xin and Wenying Pan and Xianli Bian and Qianqian Yuan and Feng Long and Na Liu and Yan Li and Fei Gao and Chengwei Zou and Yaoqin Gong and Qiji Liu},
  journal={Scientific reports},
  year={2015},
  volume={5},
  pages={
          17194
        }
}
ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3) is a universally confirmed susceptibility gene for asthma and has recently emerged as a crucial modulator in lipid metabolism, inflammation and endoplasmic reticulum (ER) stress-the mechanisms also closely involved in atherosclerosis (AS). Here we first presented the evidence of two single nucleotide polymorphisms regulating ORMDL3 expression (rs7216389 and rs9303277) significantly associated with AS risk and the evidence of increased ORMDL3… CONTINUE READING
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Early origins of asthma (and allergy)

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