ORIGINAL ARTICLE: Glycation Endproducts, Soluble Receptor for Advanced Glycation Endproducts and Cytokines in Diabetic and Non‐diabetic Pregnancies

@article{PertyskaMarczewska2009ORIGINALAG,
  title={ORIGINAL ARTICLE: Glycation Endproducts, Soluble Receptor for Advanced Glycation Endproducts and Cytokines in Diabetic and Non‐diabetic Pregnancies},
  author={M. Pertyńska-Marczewska and E. Głowacka and M. Sobczak and K. Cypryk and J. Wilczyński},
  journal={American Journal of Reproductive Immunology},
  year={2009},
  volume={61}
}
Problem  Cytokines, advanced glycation end products (AGEs), and their receptor RAGE have been recently suggested to play a role in human pregnancy. In this study, we sought to determine the alterations of plasma AGEs, soluble RAGE (sRAGE), and proinflammatory cytokines in normal pregnancies and those complicated with type 1 diabetes mellitus. 
Activation of the receptor for advanced glycation end products system in women with severe preeclampsia.
TLDR
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Reduced soluble receptor for advanced glycation end‐products (sRAGE) scavenger capacity precedes pre‐eclampsia in Type 1 diabetes
TLDR
Reduced soluble receptor for advanced glycation end‐products (sRAGE) scavenger capacity precedes pre‐eclampsia in Type 1 diabetes and reduces the risk of pregnancy in women with type 1 diabetes. Expand
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TLDR
The results clearly demonstrate significant differences in serum sRAGE levels in physiological pregnancy and in pathological states in pregnancy, however, further studies are required demonstrate the usefulness and significance of sRAge. Expand
Soluble form of a receptor for advanced glycation end products (sRAGE) as a biomarker.
TLDR
The kinetics, regulation and pathophysiological role of sRAGE in humans is reviewed and the potential clinical utility of measuring s RAGE in various disorders as a biomarker is discussed. Expand
Critical Appraisal of Advanced Glycation End Products (AGEs) and Circulating Soluble Receptors for Advanced Glycation End Products (sRAGE) as a Predictive Biomarkers for Cardiovascular Disease in Hemodialysis Patients
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Advanced glycation end products (AGEs) and their soluble receptors (sRAGE) as early predictors of reno-vascular complications in patients with uncontrolled type 2 diabetes mellitus.
TLDR
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Changes in circulating levels of carboxymethyllysine, soluble receptor for advanced glycation end products (sRAGE), and inflammation markers in women during normal pregnancy
  • Claudia V Quintanilla-García, J. Uribarri, +4 authors M. Garay-Sevilla
  • Medicine
  • The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2018
TLDR
This study confirms that normal pregnancy is accompanied by insulin resistance (IR) and significant increase in lipid profile, and demonstrates that circulating levels of CML and sRAGE decreased significantly at the end of pregnancy. Expand
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  • Medicine
  • The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2019
TLDR
During pregnancy, the changes observed in the levels of AGEs were different between GDM and normal pregnancies, and plasma levels of TNF-α and hs-CRP were significantly higher in the GDM group than in the NGT group. Expand
Accumulation of Advanced Glycation End Products Involved in Inflammation and Contributing to Severe Preeclampsia, in Maternal Blood, Umbilical Blood and Placental Tissues
TLDR
AGEs and RAGE appear to act as important mediators in regulating the inflammatory pathways of preeclampsia. Expand
Serum Fluorescent Advanced Glycation End (F-AGE) products in gestational diabetes patients.
TLDR
It was not possible to distinguish women with gestational diabetes from the healthy controls on the basis of serum F-AGE concentrations, and AGE concentrations did not change significantly during the pregnancy. Expand
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References

SHOWING 1-10 OF 28 REFERENCES
Soluble receptor for advanced glycation end products: from disease marker to potential therapeutic target.
TLDR
The state of the art in the use of sRAGE as a disease marker is presented and the therapeutic potential of targeting sRA GE for the treatment of inflammation-related diseases such as atherosclerosis, arthritis and Alzheimer's disease is discussed. Expand
The Receptor for Advanced Glycation End Products (RAGE) Is Elevated in Women with Preeclampsia
TLDR
The data suggest that since RAGE activation can induce similar pathophysiologic changes to those observed in women with preeclampsia, elevated RAGE protein may be contributing to the vascular dysfunction in preeClampsia. Expand
Serum Levels of sRAGE, the Soluble Form of Receptor for Advanced Glycation End Products, Are Associated with Inflammatory Markers in Patients with Type 2 Diabetes
TLDR
It is demonstrated for the first time that serum levels of sRAGE are positively associated with MCP-1 and TNF-α levels in type 2 diabetic patients, suggesting the possibility that sRAge level may become a novel biomarker of vascular inflammation in type 1 diabetic patients. Expand
Soluble receptor for advanced glycation end products (sRAGE) and endogenous secretory RAGE (esRAGE) in amniotic fluid: modulation by infection and inflammation
TLDR
Findings suggest changes in the amniotic fluid concentration of sRAGE and esRAGE may represent part of the immune response to intra-amniotic infection/inflammation. Expand
Positive association between serum levels of advanced glycation end products and the soluble form of receptor for advanced glycation end products in nondiabetic subjects.
TLDR
The present study is the first demonstration that serum sRAGE levels were positively associated with circulating AGEs in the nondiabetic general population. Expand
The receptor for advanced glycation end products (RAGE) system in women with intraamniotic infection and inflammation.
TLDR
It is determined that the competitive inhibitor sRAGE is temporally regulated during gestation and that its AF levels are not influenced by the presence of either intra-amniotic infection or inflammation. Expand
Advanced glycation end products induce secretion of chemokines and apoptosis in human first trimester trophoblasts.
TLDR
These AGE-mediated changes in trophoblasts may lead to impairment of implantation and placentation and NOS inhibitors or nafamostat mesilate may modify these effects. Expand
AGE, RAGE, and ROS in diabetic nephropathy.
TLDR
It is predicted that new therapies designed to target AGEs, including AGE formation inhibitors and cross-link breakers, as well as targeting ROS using novel highly specific antioxidants, will become part of the treatment regimen for diabetic renal disease. Expand
Advanced glycation endproducts mediate pro-inflammatory actions in human gestational tissues via nuclear factor-kappaB and extracellular signal-regulated kinase 1/2.
TLDR
Investigation of the effects of AGE on 8-isoprostane (a marker of oxidative stress), pro-inflammatory cytokine and prostaglandin release in human gestational tissues and the signalling pathways involved found protein kinases and the NF-kappaB pathway play an essential role in AGE signalling in human Gestational tissues. Expand
Detection of feto-maternal infection/inflammation by the soluble receptor for advanced glycation end products (sRAGE): results of a pilot study
Abstract Objective: The receptor for advanced glycation end products, RAGE, plays an important role in the pathogenesis of several diseases. sRAGE, soluble receptor for advanced glycation endExpand
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