author={Walter Bradford Cannon},
  journal={Physiological Reviews},
  • W. Cannon
  • Published 1 July 1929
  • Biology
  • Physiological Reviews
Biologists have long been impressed by the ability of living beings to maintain their own stability. The idea that disease is cured by natural powers, by a vis medicatrix naturae, an idea which was held by Hip pocrates, implies the existence of agencies ready to operate correctively when the normal state of the organism is upset. More precise modern references to self-regulatory arrangements are found in the writings of prominent physiologists. Pfluger (1877) recognized the natural adjustments… 

Prologue: The Guardians of Homeostasis

The core of this homeostatic system refers to pattern recognition molecules (PRMs) which possess the ability to sense ancient molecular motifs derived from microbes (MAMPs) as well as sterile insult-induced damage-associated molecular patterns (DAMPs).

Homeostatic Mechanisms in the Cochlea

The inner ear, as suggested by Hawkins (1973), possesses a variety of microhomeostatic mechanisms that sustain the integrity, sensitivity, and dynamic range of the organ of Corti and make possible its function as a transducer, although they do not include the transduction process itself.

Evolution of Physiological and Behavioural Mechanisms in Vertebrate Body Fluid Homeostasis

The term homeostasis, defined as “... the physiological rather than the physical arrangements for attaining constancy”, was introduced by Cannon 1929, and went on to say why use of a special word was justified.

Introductory Chapter: Homeostasis

In 1870, Claude Bernard described the basic principles of physiological regulation, evidencing the body’s need to maintain a stable internal environment. This allows life processes to function

Mechanisms of interorgan crosstalk in health and disease

The development of multicellularity of organisms during evolution brought about the need for coordinated activity of different cell types and organs in order to adapt to changing external and internal microenvironmental conditions and the role that interorgan communication plays in this process is reviewed.

The concept of the organism in physiology

Focus on the function of fully developed or adult organisms has been accompanied by a relative neglect of developmental processes, and incorporation of evolutionary, ecological, and developmental perspectives into the study of organisms might help to unite physiology more closely with the other biological sciences and lead to a richer and fuller understanding of organisms.

Physiological Adaptation at the Molecular Level: The Frontier Where Research on Differentiation and Malignancy Meet

  • V. Potter
  • Biology
    Perspectives in biology and medicine
  • 1981
There is need again for a conceptual scheme that will integrate what some know as homeostasis with the related but newer molecufar discoveries of gene expression, this lecture was given at the meeting of the Southwest Section of the American Association for Cancer Research, Albuquerque, New Mexico, November 15-16, 1979, at which time the author was presented the Fourth Annual Noble Foundation Research Recogni- tion Award.

Cochlear Homeostasis and Homeostatic Disorders

Homeostasis is the nearly all-encompassing control of vital parameters and is maintained on more than one level, for example, on the level of the entire body as well as on thelevel of individual cells.

3 Cochlear Homeostasis and Homeostatic Disorders

Homeostasis is the nearly all-encompassing control of vital parameters and is maintained on more than one level, for example, on the level of the entire body as well as on thelevel of individual cells.

Exploring the Concept of Homeostasis and Considering its Implications for Economics

In its standard format, the concept of homeostasis refers to the ability, present in all living organisms, of continuously maintaining certain functional variables within a range of values compatible



Elements of Physical Biology.

The author has the problem of evolution always before him, and considers analytically the effect on population of a change in the behaviour of individuals in Elements of Physical Biology.

The Secretion of the Urine

An admirable account of the kidney is given, and the various views held as to its functions are discussed, as well as those associated with the historic names of Bowman and Ludwig.

The Physiology of Muscular Exercise

IT may reasonably be doubted whether any two physiologists would deal with the subject of muscular exercise along similar lines, nor is it desirable that this should be so, the subject being so

The Control of Hunger in Health and Disease

This volume presents "a summary of the work on the stomach, with special reference to hunger and appetite, carried out in the Hull Physiological Laboratory of the University of Chicago during the last four years," in the light of biological and clinical literature.


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  • 1911

Diabetes : its pathological physiology

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  • d. Physiol., xxiv, 733. BRITTON, S. W. 1925. Amer. Journ. Physiol., lxxiv, 291. 1928. Amer. Journ. Physiol., lxxxvi, 340. BULATAO, E. AND W. B. CANNON. 1925. Amer. Joura. Physiol., lxxii, 295.
  • 1925

Pfliiger's Arch., xv