ORF85 of HearNPV encodes the per os infectivity factor 4 (PIF4) and is essential for the formation of the PIF complex.

@article{Huang2012ORF85OH,
  title={ORF85 of HearNPV encodes the per os infectivity factor 4 (PIF4) and is essential for the formation of the PIF complex.},
  author={Huachao Huang and Manli Wang and Fei Deng and Hualin Wang and Zhihong Hu},
  journal={Virology},
  year={2012},
  volume={427 2},
  pages={217-23}
}
ORF85 of Helicoverpa armigera nucleopolyhedrovirus (HearNPV) encodes a homologue of the per os infectivity factor 4 (PIF-4) of Autographa californica multiple nucleocapsid nucleopolyhedrovirus (AcMNPV). In this paper, the functions of HA85, particularly in relation to oral infection and interactions with other PIFs were investigated. An ha85-disrupted recombinant HearNPV was generated and resulted in a complete loss of oral infectivity. Western blotting and co-immunoprecipitation (Co-IP… CONTINUE READING

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