ORF4-protein deficient PCV2 mutants enhance virus-induced apoptosis and show differential expression of mRNAs in vitro.

@article{Gao2014ORF4proteinDP,
  title={ORF4-protein deficient PCV2 mutants enhance virus-induced apoptosis and show differential expression of mRNAs in vitro.},
  author={Zhangzhao Gao and Qinfang Dong and Yonghou H Jiang and Tanja Opriessnig and Jingxiu Wang and Yanping Quan and Zongqi Yang},
  journal={Virus research},
  year={2014},
  volume={183},
  pages={56-62}
}
Porcine circovirus type 2 (PCV2) is the essential infectious agent of PCV associated disease (PCVAD). During previous in vitro studies, 11 RNAs and four viral proteins have been detected in PCV2-infected cells. Open reading frame (ORF) 4 is 180bp in length and has been identified at the transcription and the translation level. It overlaps completely with ORF3, which has a role in virus-induced apoptosis. In this study, start codon mutations (M1-PCV2) or in-frame termination mutations (M2-PCV2… CONTINUE READING
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